by Anais MAX | Sep 14, 2021 | Publications
Identification of a small molecule splicing inhibitor targeting UHM domains Abstract Splicing factor mutations are frequent in myeloid neoplasms, blood cancers and solid tumors. Cancer cells harboring these mutations present a particular vulnerability to drugs that...
by Anais MAX | Sep 7, 2021 | Publications
The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation Abstract TDP-43 is a nuclear RNA-binding protein that forms neuronal cytoplasmic inclusions in two major neurodegenerative diseases, ALS and FTLD. While the self-assembly of TDP-43...
by Anais MAX | Mar 19, 2021 | Publications
Lin28, a major translation reprogramming factor, gains access to YB-1-packaged mRNA through its cold-shock domain Abstract The RNA-binding protein Lin28 (Lin28a) is an important pluripotency factor that reprograms translation and promotes cancer progression. Although...
