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The FEBS JOURNAL | Identification of a small molecule splicing inhibitor targeting UHM domains

by Anais MAX | Sep 14, 2021 | Publications

Identification of a small molecule splicing inhibitor targeting UHM domains Abstract Splicing factor mutations are frequent in myeloid neoplasms, blood cancers and solid tumors. Cancer cells harboring these mutations present a particular vulnerability to drugs that...

ELIFE | The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation

by Anais MAX | Sep 7, 2021 | Publications

The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation Abstract TDP-43 is a nuclear RNA-binding protein that forms neuronal cytoplasmic inclusions in two major neurodegenerative diseases, ALS and FTLD. While the self-assembly of TDP-43...

COMMUNICATIONS BIOLOGY | Lin28, a major translayion reprogramming factor, gains acceess to YB-a packaged mRNA through its cold-shock domain

by Anais MAX | Mar 19, 2021 | Publications

Lin28, a major translation reprogramming factor, gains access to YB-1-packaged mRNA through its cold-shock domain Abstract The RNA-binding protein Lin28 (Lin28a) is an important pluripotency factor that reprograms translation and promotes cancer progression. Although...

Latest News

  • SYNSIGHT SECURES $1.5 MILLION FUNDING ROUND TO ADVANCE ITS DRUG DISCOVERY TECHNOLOGY PLATFORM AND EXPAND ITS PIPELINE
  • THE IMAGINE INSTITUTE AND SYNSIGHT JOIN FORCES TO GO FURTHER IN DRUG DISCOVERY
  • Synsight and MCule combine their AI platform and compound management to boost drug discovery
  • NOUVELLE SELECTION IA POUR SYNSIGHT AVEC LE “TRUSTED AI START-UP” DECERNé PAR HUB FRANCE IA ET LA EUROPEAN AI STARTUP LANDSCAPE
  • SIGNING OF A MEMORANDUM OF UNDERSTANDING BETWEEN SYNSIGHT AND BIOCUBATE TO DEVELOP AI DRUG DISCOVERY IN ASIAN MARKET

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